Our data show that a group of HAHPs in the coronaviral genome potentially has a regulatory role in viral propagation. Furthermore, one of the SARS-CoV-2 HAHPs specifically inhibited viral RNA synthesis by accumulating at the site of viral RNA synthesis.

Two and three HAHPs derived from SARS-CoV-2 and MERS-CoV, respectively, specifically interacted with both the SARS-CoV-2 and MERS-CoV S proteins and inhibited their membrane fusion activity.

We selected and analyzed five and six HAHPs encoded in the S gene regions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively. These HAHPs can theoretically be expressed from non-canonical sub-genomic (sg)RNAs that are synthesized in substantial amounts in infected cells.

Please do not bug us with these sort of requests.In this study, we show that the coronavirus (CoV) genome may encode many functional hydrophobic alpha-helical peptides (HAHPs) in overlapping reading frames of major coronaviral proteins throughout the entire viral genome. So, how can I donate?Ĭlick here to learn more about donating. You must donate to be able to download from our server. We are allocating all funds to the download server for donors since we pay out of pocket to keep everything running. How are download links prevented from expiring?Īll games are available to be voted on for a re-upload 30 days after they were last uploaded to guard against dead links. This is to deter bots from scraping the site and issuing a DMCA takedown on filehosters. Why do I have to complete captcha to view download links? Every installer is checked for authenticity from GOG.com and integrity before uploading. OMG! My antivirus software is reporting I downloaded malware! What gives? No, this would cost even more time and money. Please use JDownloader 2 to download game files and 7-Zip to extract them. What is the easiest way to download or extract files? Simple! To upload and share games from GOG.com. Frequently Asked Questions What is the purpose of this site?

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